Publikationen TKTL1 & Apo10/Публикации TKTL1 & Apo10

Офтальмология

  • Lange CA et al: Enhanced TKTL1 Expression in Malignant Tumors of the Ocular Adnexa Predicts Clinical Outcome.Ophthalmology. 2012 Sep;119(9):1924-9. Epub 2012 Jun 1. Universitätsklinikum Freiburg

Эндокриноллогия

Рак щитовидной железы.

  • Zerilli M et al: Increased expression of transketolase-like-1 in papillary thyroid carcinomas smaller than 1.5 cm in diameter is associated with lymph-node metastases. Cancer. 2008 Sep 1;113(5):936-44

Гастроэнтерология

Рак прямой кишки и рак толстого кишечника.

  • Jansen N und Coy JF: Diagnostic use of EDIM-blood test for early detection of colon cancer metastasis. Future Oncol. (2013) in press
  • Schwaab J et al: Expression of Transketolase like gene 1 (TKTL1) predicts disease-free survival in patients with locally advanced rectal cancer receiving neoadjuvant chemoradiotherapy. BMC Cancer 2011, 11:363. Universitätsmedizin Mannheim
  • Diaz-Moralli S et al: Transketolase-like 1 expression is modulated during colorectal cancer progression and metastasis formation. PLoS One. 2011;6(9):e25323. Epub 2011 Sep 27
  • Xu X et al: Transketolase-like protein 1 (TKTL1) is required for rapid cell growth and full viability of human tumor cells. Int J Cancer. 2009 Mar 15;124(6):1330-7. Deutsches Krebsforschungszentrum Heidelberg
  • Langbein S et al: Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted. Br J Cancer. 2006 Feb 27;94(4):578-85. Universitätsmedizin Mannheim

Рак желудка:

  • Yuan W et al: Silencing of TKTL1 by siRNA inhibits proliferation of human gastric cancer cells in vitro and in vivo. Cancer Biol Ther. 2010 May;9(9):710-6. Epub 2010 May
  • Staiger WI et al: Expression of the mutated transketolase TKTL1, a molecular marker in gastric cancer. Oncol Rep. 2006 Oct;16(4):657-61. Universitätsmedizin Mannheim

Гинекология

Рак молочной железы:

  • Feyen O et al: EDIM-TKTL1 blood test: a noninvasive method to detect upregulated glucose metabolism in patients with malignancies. Future Oncol. (2012) 8(10), 1349-1359. Rhönklinikum Bad Berka
  • Feyen O et al: EDIM blood test: a non-invasive method to detect patients with malignancies. Cell Symposia July 6-8, 2012: Poster
  • Rotmann A et al: Apo10 — a new biomarker for early detection of disorders of cell proliferation and solid tumours. FIGO 2012: Submission Number/Control ID: 1358244.
  • Schmidt M et al: Glycolytic phenotype in breast cancer: activation of Akt, up-regulation of GLUT1, TKTL1 and down-regulation of M2PK. J Cancer Res Clin Oncol. 2010 Feb;136(2):219-25. Epub 2009 Aug 5. Universitätsklinikum Würzburg
  • Rotmann A et al: TKTL1 — a new biomarker and its relevance in the daily gynaecological practice. Poster FIGO 2009
  • Földi M et al: Transketolase protein TKTL1 overexpression: A potential biomarker and therapeutic target in breast cancer. Oncol Rep. 2007 Apr;17(4):841-5. Universitätsklinikum Freiburg

Рак эндометрия:

  • Krockenberger M et al: Expression of transketolase-like 1 protein (TKTL1) in human endometrial cancer. Anticancer Res. 2010 May;30(5):1653-9. Universitätsklinikum Würzburg

Рак яичников:

  • Schmidt M et al: Glucose metabolism and angiogenesis in granulosa cell tumors of the ovary: activation of Akt, expression of M2PK, TKTL1 and VEGF. Eur J Obstet Gynecol Reprod Biol. 2008 Jul;139(1):72-8. Epub 2008 Apr 3. Universitätsklinikum Würzburg
  • Krockenberger M et al: Transketolase-like 1 expression correlates with subtypes of ovarian cancer and the presence of distant metastases. Int J Gynecol Cancer 2007 Jan-Feb;17(1):101-6. Universitätsklinikum Würzburg

Рак шейки матки:

  • Chen H et al: Overexpression of transketolase-like gene 1 is associated with cell proliferation in uterine cervix cancer. J Exp Clin Cancer Res. 2009 Mar 30;28:43.
  • Kohrenhagen N et al: Expression of transketolase-like 1 (TKTL1) and p-Akt correlates with the progression of cervical neoplasia. J Obstet Gynaecol Res. 2008 Jun;34(3):293-300. Universitätsklinikum Würzburg

Рак головы и шеи:

  • Grimm M et al: Transketolase-like protein 1 expression in recurrent oral squamous cell carcinoma after curative resection: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Jul 20. Epub ahead of print. Universitätsklinikum Tübingen
  • Hartmannsberger D et al: Transketolase-like protein 1 confers resistance to serum withdrawal in vitro. Cancer Lett. 2011 Jan 1;300(1):20-9. Epub 2010 Sep 29. Universitätsklinikum München
  • Sun W et al: TKTL1 is activated by promoter hypomethylation and contributes to head and neck squamous cell carcinoma carcinogenesis through increased aerobic glycolysis and HIF1alpha stabilization. Clin Cancer Res. 2010 Feb 1;16(3):857-66. Epub 2010 Jan 26
  • Smith IM et al: Coordinated activation of candidate proto-oncogenes and cancer testes antigens via promoter demethylation in head and neck cancer and lung cancer. PLoS One. 2009;4(3):e4961. Epub 2009 Mar 23
  • Völker HU et al: Overexpression of transketolase TKTL1 is associated with shorter survival in laryngeal squamous cell carcinomas. Eur Arch Otorhinolaryngol. 2007 Dec;264(12):1431-6. Epub 2007 Jul 18. Universitätsklinikum Würzburg

Неврология

Опухоли головного мозга:

  • Wanka C et al: Tp53-induced glycolysis and apoptosis regulator (TIGAR) protects glioma cells from starvationinduced cell death by upregulating respiration and improving cellular redox homeostasis. J Biol Chem. 2012 Sep 28;287(40):33436-46. Epub 2012 Aug 10.
  • Wani K et al: A prognostic gene expression signature in infratentorial ependymoma. For the Collaborative Ependymoma Research Network. Acta Neuropathol. 2012 May;123(5):727-38. Epub 2012 Feb 10.
  • Völker HU et al: Expression of transketolase-like 1 and activation of Akt in grade IV glioblastomas compared with grades II and III astrocytic gliomas. Am J Clin Pathol. 2008 Jul;130(1):50-7. Universitätsklinikum Würzburg

Пульмонология

Рак легких:

  • Feyen O et al: EDIM-TKTL1 blood test: a noninvasive method to detect upregulated glucose metabolism in patients with malignancies. Future Oncol. (2012) 8(10), 1349-1359. Rhönklinikum Bad Berka
  • Feyen O et al: EDIM blood test: a non-invasive method to detect patients with malignancies. Cell Symposia July 6-8, 2012: Poster
  • Kayser G et al: Poor outcome in primary non-small cell lung cancers is predicted by transketolase TKTL1 expression. Pathology. 2011 Dec;43(7):719-24. Universitätsklinikum Freiburg
  • Kayser G et al: Lactate-dehydrogenase 5 is overexpressed in non-small cell lung cancer and correlates with the expression of the transketolase-like protein 1. Diagn Pathol. 2010 Apr 12;5:22. Universitätsklinikum Freiburg
  • Prasad V et al: Transketolase-like 1 (TKTL1), a new intracellular marker for staging of non-small cell lung cancer (NSCLC): Correlation with metabolic tumor size on F-18 FDG PET/CT. Poster SNM 2010. Rhönklinikum Bad Berka
  • Smith IM et al: Coordinated activation of candidate proto-oncogenes and cancer testes antigens via promoter demethylation in head and neck cancer and lung cancer. PLoS One. 2009;4(3):e4961. Epub 2009 Mar 23

Урология

Рак предстательной железы:

  • Arnoldt J: Therapy monitoring and early detection of metastasis using tumor protein detection in macrophages. Anticancer Research ISSN 0250-7005: 2011 May:2012
  • Langbein S et al: Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted. Br J Cancer. 2006 Feb 27;94(4):578-85. Universitätsmedizin Mannheim

Нефробластома:

  • Wu HT et al: Anaplastic nephroblastomas express transketolase-like enzyme 1. J Clin Pathol. 2009 May;62(5):460-3. Epub 2009 Jan 12

Почечная карцинома:

  • Langbein S et al: Metastasis is promoted by a bioenergetic switch: new targets for progressive renal cell cancer. Int J Cancer. 2008 Jun 1;122(11):2422-8
Publikationen TKTL1 & Apo10/Публикации TKTL1 & Apo10