Ketogene Ernährung / Metabolische Therapie/Метаболическая терапия

Ketogene Ernährung / Metabolische Therapie/Метаболическая терапия

• Dr Johannes Coy. Implications of nutrition on the incidence and treatment of cancer.
• Schmidt M et al.: Effects of a ketogenic diet on the quality of life in 16 patients with advanced cancer: A pilot trial. Nutrition & Metabolism 2011; 8:54
• Rainer J. Klement . Restricting carbohydrates to fight head and neck cancer—is this realistic?
• Rieger J et al.: ERGO: A pilot study of ketogenic diet in recurrent glioblastome. Int. J. Oncol., DOI: 10.3892/ijo.2014.2382
• Abdelwahab MG et al.: The ketogenic diet is an effective adjuvant to radiation therapy for the treatment of malignant glioma. 2012 PLoS One 7:e36197
• Allen BG et al.: Ketogenic diets enhance oxidative stress and radio-chemo-therapy responses in lung cancer xenografts. Clin Cancer Res. 2013 Jul 15;19(14):3905-13
• Breitkreutz R et al.: Effects of a high-fat diet on body composition in cancer patients receiving chemotherapy: a randomized controlled study. Wien Klin Wochenschr. 2005 Oct;117(19-20):685-92
• Champ CE et al.: Targeting metabolism with a ketogenic diet during the treatment of glioblastoma multiforme. J Neurooncol 2014 DOI 10.1007/s11060-014-1362-0
• Champ CE et al.: Nutrient restriction and radiation therapy for cancer treatment: when less is more. The Oncologist 2013, 18, 97–103
• Chang HAT et al.: Ketolytic and glycolytic enzymatic expression profiles in malignant gliomas: implication forketogenic diet therapy. Nutr Metab (Lond). 2013 Jul 5;10(1):47
• Dorr C et al.: Synthetic lethal metabolic targeting of cellular senescence in cancer therapy. doi:10.1038/nature12437
• El Mjiyad N et al.: Sugar-free approaches to cancer cell killing. Oncogene 2011, 30, 253-264
• Emond JA et al.: Risk of Breast Cancer Recurrence Associated with Carbohydrate Intake and Tissue Expression of IGF-1 Receptor. Cancer Epidemiol Biomarkers Prev. 2014 Apr 22
• Fine EJ et al.: Acetoacetate reduces growth and ATP concentration in cancer cell lines which over-express uncoupling protein 2. Cancer Cell Int 2009, 9:14
• Fine EJ et al.: Targeting insulin inhibition as a metabolic therapy in advanced cancer: A pilot safety and feasibility dietary trial in 10 patients. Nutrition 2012, 28:1028-35
• Fogg VC et al.: Mitochondria in cancer: at the crossroads of life and death. Chin J Cancer. 2011 Aug;30(8):526-39
• Freedland SJ et al.: Carbohydrate restriction, prostate cancer growth, and the insulin-like growth factor axis. Prostate. 2008 Jan 1;68(1):11-9
• Gatenby RA et al.: Why do Cancers have high aerobic glycolysis? Nat Rev Cancer. 2004 Nov;4(11):891-9
• Ho VW et al.: A Low Carbohydrate, High Protein Diet Slows Tumor Growth and Prevents Cancer Initiation. Cancer Res; 71(13) July 1, 2011
• Husain Z et al.: Tumor-derived lactate modifies antitumor immune response: effect on myeloid-derived suppressor cells and NK cells. J Immunol. 2013 Aug 1;191(3):1486-95
• Hsu PP et al.: Cancer Cell Metabolism: Warburg and Beyond. Cell, Volume 134, Issue 5, 703-707, 5 September 2008
• Kankova K et al.: Cancer as a Metabolic Disease and Diabetes as a Cancer Risk? Klin Onkol 2012; 25 (Suppl 2):2S26-2S31
• Klement RJ et al.: Calories, carbohydrates, and cancer therapy with radiation: exploiting the five R’s through dietary manipulation. Cancer and Metastasis Reviews. 2014 Jan 17
• Klement RJ et al.: Is there a role for carbohydrate restriction in the treatment and prevention of cancer? Nutrition & Metabolism 2011, 8:75
• Lee C et al.: Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy.Sci Transl Med. 2012 Mar 7;4(124):124ra27. Epub 2012 Feb 8
• Leprivier G et al.: The eEF2 Kinase Confers Resistance to Nutrient Deprivation by Blocking Translation Elongation Cell Vol 153, Issue 5, 1064-1079
• Longo VD et al.: Calorie restriction and cancer prevention: metabolic and molecular mechanisms. Trends Pharmacol Sci. 2010 February; 31(2): 89–98
• Li B et al.: Downregulation of the Werner syndrome protein induces a metabolic shift that compromises redox homeostasis and limits proliferation of cancer cells. Aging Cell 2013, 1-12
• Lu W et al.: Cancer Metabolism and Its Therapeutic Implications. J Cell Sci Ther 2013, 4:2
• Maurer et al.: Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy. BMC Cancer 2011, 11:315
• Meijer T et al.: Targeting Hypoxia, HIF-1, and Tumor Glucose Metabolism to Improve Radiotherapy Efficacy. Clin Cancer Res 2012;18:5585-5594
• Oleksyszyn J: The complete control of glucose level utilizing the composition of ketogenic diet with the gluconeogenesis inhibitor, the anti-diabetic drug metformin, as a potential anti-cancer therapy. Med Hypotheses. 2011 Aug;77(2):171-3
• Onodera Y et al.: Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways. J Clin Invest. 2014;124(1):367–384
• Otto C et al.: Experimentelle Untersuchungen zur Verstoffwechselung von Ketonkorpern und Laktat durch Tumorzellen des Gastrointestinaltrakts. Aktuelle Ernahrungsmedizin 2014; 39:51-59
• Otto C et al.: Die ketogene Diat als Ernahrungsoption fur Tumorpatienten. Weimann A et al.:Krankheitsbedingte Mangelernahrung, Pabst Publishers, 1. Aufl., 2010, 175 – 197
• Otto C et al.: Growth of human gastric cancer cells in nude mice is delayed by a ketogenic diet supplemented with omega-3 fatty acids and medium-chain triglycerides. BMC Cancer 2008, 8:122
• Paoli A et al.: Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets. European Journal of Clinical Nutrition (2013) 67, 789–796
• Phan LM et al.: Cancer metabolic reprogramming: importance, main features, and potentials for precise targeted anti-cancer therapies. Cancer Biol Med 2014;11:1-19.
• Poff AM et al.: Ketone Supplementation Decreases Tumor Cell Viability and Prolongs Survival of Mice with Metastatic Cancer. Int J Cancer 2014 Feb 26. doi: 10.1002/ijc.28809. [Epub ahead of print]
• Poff A et al.: The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice with Systemic Metastatic Cancer. PLOS ONE June 2013, Volume 8, Issue 6. e65522
• Raffaghello L et al.: Fasting and differential chemotherapy protection in patients. Cell Cycle 2010, 9:22, 4474-4476
• Rossi-Fanelli F et al.: Effect of energy substratemanipulation on tumor cell proliferation in parenterally fed cancer patients Clinical Nutrition (1991) 10, 228–232.
• Safdie FM et al.: Fasting enhances the response of glioma to chemo- and radiotherapy. 2012 PLoS One 7:e44603
• Safdie FM et al.: Fasting and Cancer Treatment in Humans: A Case series report. AGING 2009, 1, 12
• Schroeder U et al.: Decline of lactate in tumor tissue after ketogenic diet: in vivo microdialysis study in patients with head and neck cancer. Nutr Cancer, 2013;65(6):843-9
• Seyfried TN et al.: Cancer as a metabolic disease. Nutr Metab (Lond). 2010 Jan 27;7:7
• Seyfried TN et al.: Targeting energy metabolism in brain cancer: review and Hypothesis. Nutr Metab (Lond). 2005 Oct 21;2:30
• Shi Y et al.: Starvation-induced activation of ATM/Chk2/p53 signaling sensitizes cancer cells to cisplatin. BMC Cancer 2012, 12:571
• Simone BA et al.: Selectively starving cancer cells through dietary manipulation: methods and clinical implications. Future Oncol. 2013 Jul;9(7):959-76
• Wanka C et al.: Tp53-induced glycolysis and apoptosis regulator (TIGAR) protects glioma cells from starvationinduced cell death by upregulating respiration and improving cellular redox homeostasis. The Journal of Biological Chemistry, 2012, 287, 33436-33446
• Woolf EC et al.: The Ketogenic Diet for the Treatment of Malignant Glioma. J Lipid Res. 2014 Feb 6.
• Zuccoli G et al.: Metabolic management of glioblastoma multiforme using standard therapy together with a restricted ketogenic diet: Case Report. Nutr Metab (Lond). 2010 Apr 22;7:33